DAFTAR ISI
KATA PENGANTAR....................................................................................iii
DAFTAR ISI ..................................................................................................iv
BAB 1 PENGANTAR FARMAKOLOGI: DEFINISI, SEJARAH, DAN
RUANG LINGKUP.........................................................................................1
Sejarah Farmakologi.........................................................................................2
Definisi dan Ruang Lingkup Farmakologi..............................................4
Istilah Penting Dalam Farmakologi...........................................................5
Obat ........................................................................................................................6
Daftar Pustaka.....................................................................................................9
Profil Penulis.....................................................................................................10
BAB 2 FARMAKOKINETIKA....................................................................11
Pendahuluan .....................................................................................................12
Farmakokinetika dan Farmakodinamika............................................12
Pengukuran Konsentrasi Obat..................................................................14
Konsep Dasar Farmakokinetika...............................................................14
Manfaat Dasar Farmakokinetik Dalam Bidang Klinis ...................18
Daftar Pustaka..................................................................................................21
Profil Penulis.....................................................................................................22
BAB 3 FARMAKODINAMIK.....................................................................23
Pendahuluan Farmakodinamik................................................................24
Mekanisme Kerja Obat: Interaksi Obat dengan Reseptor ...........24
Jalur Transduksi Sinyal (Signal Transduction Pathway)..............27
Parameter Farmakodinamik .....................................................................28
Faktor yang Memengaruhi Farmakodinamik ...................................28
Aplikasi Klinis Farmakodinamik .............................................................29
Studi Kasus dalam Farmakodinamik.....................................................29
Faktor yang Memengaruhi Farmakodinamik ...................................31
Kurva Dosis Respons.....................................................................................32
Efikasi dan Potensi Obat..............................................................................32
Modifikasi Protein dan Regulasi Gen ....................................................33
Efek Obat pada Sistem Enzim ...................................................................34
Farmakodinamik pada Berbagai Sistem Organ................................35
v
Daftar Pustaka..................................................................................................37
Profil Penulis.....................................................................................................38
BAB 4 FARMAKOTERAPI BERBASIS BUKTI (EVIDENCE BASED
MEDICINE)...................................................................................................39
Pendahuluan .....................................................................................................40
Prinsip Dasar Farmakoterapi Berbasis Bukti....................................41
Proses Penerapan Farmakoterapi Berbasis Bukti..........................42
Daftar Pustaka..................................................................................................49
Profil Penulis.....................................................................................................52
BAB 5 DOSIS DAN FORMULASI OBAT.................................................53
Pendahuluan .....................................................................................................54
Faktor yang Memengaruhi Penentuan Dosis ....................................54
Formulasi Obat.................................................................................................59
Metode Perhitungan Dosis .........................................................................62
Jenis-jenis Dosis...............................................................................................67
Dosis pada Populasi Khusus ......................................................................67
Daftar Pustaka..................................................................................................70
Profil Penulis.....................................................................................................71
BAB 6 FARMAKOLOGI SISTEM SARAF OTONOM ............................72
Sistem Saraf Otonom.....................................................................................73
Farmakologi Sistem Saraf Otonom.........................................................76
Daftar Pustaka..................................................................................................82
Profil Penulis.....................................................................................................83
BAB 7 FARMAKOLOGI SISTEM KARDIOVASKULAR.......................84
Pendahuluan .....................................................................................................85
Sistem Kardiovaskular .................................................................................85
Pembuluh Darah..............................................................................................86
Darah.....................................................................................................................86
Daftar Pustaka..................................................................................................95
Profil Penulis.....................................................................................................97
BAB 8 FARMAKOLOGI SISTEM PERNAPASAN..................................98
Anatomi dan Fisiologi Sistem Pernapasan .........................................99
Mekanisme dan Fungsi Pertukaran Gas............................................101
Patofisiologi Gangguan Pernapasan ...................................................102
Farmakologi Dasar Sistem Pernapasan ............................................103
Terapi Oksigen ..............................................................................................111