Journal of Biomedicine and Translational Research (JBTR) is an open access, international peer-reviewed journal that considers articles on: clinical medicine, molecular medicine, tropical medicine, infectious diseases, cardiovascular medicine, molecular biology, genetics, immunology, microbiology, biochemistry, and pharmacotherapy with particular interest on the link between clinical and basic research called translational research. The journal publishes articles on a wide range of subjects of interest to researchers and clinical practitioners. Papers from any institution related to the field above are welcome, collaborative research is more appreciated.

In the present time, due to rapid progress of genomic research and medical services globally, the JBTR have collaborated scientifically with Indonesian Society of Human Genetics (InaSHG) and Indonesian Society of Internal Medicine (PAPDI) Semarang branch by inviting members of InaSHG and PAPDI to be a member of editorial board and advisory board as well as reviewers.

Table of Contents
Original Research Articles

1. Prevalence and Risk Factors of ESBL-producing Enterobacteriaceae in The Community
Nia Krisniawati, Anriani Puspita Karunia Ning Widhi

2. Effect of Aerobic Exercise on Left Ventricular Connexin43 Expression and Distribution in Juvenile and Young Adult Rats
Rustiana Tasya Ariningpraja, ‪Dewi Irawati Soeria Santoso, Ahmad Aulia Jusuf, Alfrina Hany

3. The Evaluation of Parental Acceptance Towards Children with Sex Chromosomal Disorders of Sex Development Using A Mixed-Method
Iit Fitrianingrum, Annastasia Ediati, Tri Indah Winarni, Sultana MH Faradz

Case Reports

1. Cushing’s syndrome manifesting as chronic insomnia caused by adrenal cortical adenoma with incidental pituitary microadenoma: a case report
Rizky Rakhmayanti, Tania Tedjo Minuljo, Herlina Suryawati, Alifiati Fitrikasari, Mohamad Adi Soedarso, Dody Priambada

2. B- Acute Lymphoblastic Leukemia L2 In Second Trimester of Pregnancy
Iraisa rosaria, Dwi Retnoningrum

3. Degree of coronary occlusions links to the patient clinical outcome: four cases of double culprits acute ST-segment elevation myocardial infarction
Ilham Uddin, Anindia Wardhani, Misbah Hari Cahyadi, Desy Ayu Puspitasari, Pipin Ardhianto, Udin Bahrudin, Yan Herry, Sodiqur Rifqi

Review Articles
1. Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond
Kavish Kohabir, Rob Wolthuis, Erik A. Sistermans

Letters to the Editor
1. Prerequisite Evaluation of Anaerobic Settings for Gut Microbiome Functional Studies
Muhammad Nur `Adam Hatta, Ezanee Azlina Mohamad Hanif, Siok-Fong Chin, Hui-min Neoh