The Indonesian Biomedical Journal (lnaBJ) is an open access, peer-reviewed journal that encompasses all fundamental and molecular aspects of basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms. lnaBJ is dedicated to publishing original research and review articles covering all aspects of biomedical sciences. While authors from any affiliations and country are welcomed to submit original research articles; however, review articles can only be submitted by invited authors.

InaBJ is published by the Prodia Education and Research Institute. lnaBJ has been indexed by Scopus, Clarivate, DOAJ, etc, and also has been accredited by Ministry of Education, Culture, Research and Technology of the Republic of Indonesia.

Vol 17, No 1 (2025)
Table of Contents
Review Article
Roles of Mesenchymal Stem Cell-derived Extracellular Vesicles in Cancer: Development and Target Therapy
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya

Research Article
1. Transcriptional Regulation of CYP2D6 by Nrf2 and Its Implications in Breast Cancer Therapy: Bioinformatics and Experimental Evidence
Ferbian Milas Siswanto, Maria Dara Novi Handayani, Lonah Lonah, Rita Dewi, Zita Arieselia, Linawati Hananta, Putu Suwarastra Andarisuta

2. Curcumin Enhances Antimigration of Pentagamavunon-1 by Suppressing MMP-2 and MMP-9 Expression in Triple-Negative (4T1) and Luminal A (T47D) Breast Cancer Cells
Desty Restia Rahmawati, Edy Meiyanto, Riris Istighfari Jenie, Arief Nurrochmad

3. Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model
Brian Wasita, Ratih Dewi Yudhani, Dyonisa Nasirochmi Pakha, Diana Nurrohima, Muthmainah Muthmainah, Nanang Wiyono, Shariza Fakurazi

4. HPV18 E6/E7 Mutation and Their Association with The Expression Level of Tumor Suppressor Proteins p53 and pRb among Indonesian Women with Cervical Cancer
I Nyoman Bayu Mahendra, Pande Kadek Aditya Prayudi, Ida Bagus Nyoman Putra Dwija

5. Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats
Maya Sari Mutia, Yelvreza Rastiani Sipayung, Dwi Elmiam, Widya Yanti Sihotang, Juliana Lina

6. Lower Ferrum, Selenium, and Cadmium; Higher Chromium and Lead Levels in Preeclampsia Patients’ Erythrocyte: A Cross-Sectional Study
Sandhy Prayudhana, Damar Prasmusinto, Noroyono Wibowo, Rima Irwinda, Yuditiya Purwosunu, Yudianto Budi Saroyo

7. Safety Concerns of Tectona grandis L.f. Leaf Extract as a Natural Food Colorant: Evidence of Irreversible Organ Pathology in Subchronic Toxicity Study
Candra Dwipayana Hamdin, Dandiko Galanova, Dheny Cahyo Saputro, Ivan Mambaul Munir, Arief Nurrochmad, Ika Puspitasari

8. Lacticaseibacillus rhamnosus Probiotics Improve Fasting Blood Glucose, HOMA-IR, and Reduce Body Weight in Diabetic Rat Model
Arresta Vitasatria Suastika, I Gde Raka Widiana, Anak Agung Ngurah Jaya Kusuma, Ni Nengah Dwi Fatmawati, Ketut Suastika, I Nengah Sujaya

9. Inhibition of Neurogenesis and Induction of Glial Scar Formation by Neuroinflammation Following Ischemic Stroke: Evaluation of BDNF, GFAP, HMGB1 and TNF-α Expressions
Aris Widayati, Fedik Abdul Rantam, Abdulloh Machin, Wibi Riawan