EBOOK FARMASI
Drugs and the liver - A guide to drug handling in liver dysfuntion
To make a judgement on medicine and choice of dose in an individual patient with a certain type of liver dysfunction, one must often return to first principles to make an educated guess. The aim of this book is therefore: • To enable the practitioner to assess liver function using biochemical markers (e.g. liver function tests), other tests, signs, symptoms and disease knowledge • To identify which pharmacokinetic and pharmacodynamic parameters of a drug are likely to be affected by different types of liver disease • To consider the impact of a drug’s side effects on a patient with liver disease. This book is written by pharmacists and clinicians in the field of hepatology and is designed to assist practitioners to make these decisions. It is aimed primarily at clinical pharmacists, but may be of value to anyone making medicine choices in patients with liver impairment, as well as to students of pharmacokinetics. It is not aimed at academics and does not negate the need for further investigation, but it will enable practitioners to make pragmatic choices for their patients.
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