The Indonesian Biomedical Journal (lnaBJ) is an open access, peer-reviewed journal that encompasses all fundamental and molecular aspects of basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms. lnaBJ is dedicated to publishing original research and review articles covering all aspects of biomedical sciences. While authors from any affiliations and country are welcomed to submit original research articles; however, review articles can only be submitted by invited authors.

InaBJ is published by the Prodia Education and Research Institute. lnaBJ has been indexed by Scopus, Clarivate, DOAJ, etc, and also has been accredited by Ministry of Education, Culture, Research and Technology of the Republic of Indonesia.

Vol 17, No 4 (2025)
Table of Contents
Review Article
Therapeutic Potential of Gut Microbiota in Hypertension: Mechanisms of Immune Modulation and Inflammation

Research Article
1. Early Active Exercise Improves MDA, SOD, and GSH Levels without Memory or NO Changes in Wistar Rats
Muhammad Hafiz Zuhdi Fairof, Arimi Fitri Mat Ludin, Nur Diyana Anas, Ainaa Husna, Ahmad Muhaimin Che Hasan, Amirul Hafiz Ahmad Abdullah, Farah Wahida Ibrahim, Adriyan Pramono, Nor Fadilah Rajab

2. CYP2C9 rs1057910 Genotype and Its Association with Paraclinical Characteristics in Gout Patients in the Northeast Region of Vietnam
Lan Thi Vu, Yen Thi Thu Hoang, Yen Thi Nguyen, Vien Van Nguyen, Hien Thu Nguyen, Thanh Ha Do, Tuan Phan Hoang

3. GSH-conjugation Reduces PGV-1 Cytotoxicity and Its Ability in Downregulating N-Myc, β-catenin, and p62 Protein in Huh-6 Cells
Rohmad Yudi Utomo, Edy Meiyanto, Ratna Asmah Susidarti

4. High-yield and Functional IgY Anti-S1 SARS-CoV-2 Delta Variant from Chicken Immunized with In-house Recombinant Protein
Kamaluddin Zarkasie, Teridah Ernala Ginting, Andrea Hynan Poeloengan, Febi Andriani, Aksar Chair Lages, Vina Cornelia, Anggah Nugraha, Bustanur Rosidi, Setyarina Indrasari, Chairul Anwar Nidom, Irawan Yusuf

5. FOXO1 and FYN Expression Trends in Breast Cancer Stem Cells: An Integrative Study of Single Nucleotide Polymorphism (SNP) Array and Quantitative PCR (qPCR) Analysis
Ay Ly Margaret, Septelia Inawati Wanandi, Fadilah Fadilah, Rafika Indah Paramita

6. Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients
Sabar Widodo, Nyoman Suci Widyastiti, Edward Kurnia Setiawan Limijadi, Meita Hendrianingtyas, Dwi Retnoningrum, Ariosta Ariosta, Yetty Movieta Nency

7. Hypomethylation of the Soluble Fms-like Tyrosine Kinase 1 (sFlt-1) Gene Promoter Region and Elevated sFlt-1 Placental Expression as Risk Factors for Preeclampsia
Anak Agung Ngurah Jaya Kusuma, I Made Darmayasa, I Gede Mega Putra, Anom Suardika, Evert Solomon Pangkahila, Vidya Saraswati Putri Duarsa, William William

8. Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury
Prayuda Prayuda, I Gde Raka Widiana, Ketut Suega, Yenny Kandarini, Ni Wayan Winarti, Bambang Purwanto

9. Non-Invasive Prenatal Testing with Next Generation Sequencing Methods in Birth Defect Pregnancy: A Pilot Study
Anom Suardika, Anak Agung Ngurah Jaya Kusuma, Ni Gusti Ayu Manik Ermayanti, Endang Sri Widiyanti, I Gusti Ngurah Agung Satria Wibawa, Divika Silvana, Anak Agung Gede Raka Budayasa, Ni Nyoman Ayu Dewi, I Made Jawi, H. Sunny Sun, Yen-An Tang