The Indonesian Biomedical Journal (lnaBJ) is an open access, peer-reviewed journal that encompasses all fundamental and molecular aspects of basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms. lnaBJ is dedicated to publishing original research and review articles covering all aspects of biomedical sciences. While authors from any affiliations and country are welcomed to submit original research articles; however, review articles can only be submitted by invited authors.

InaBJ is published by the Prodia Education and Research Institute. lnaBJ has been indexed by Scopus, Clarivate, DOAJ, etc, and also has been accredited by Ministry of Education, Culture, Research and Technology of the Republic of Indonesia.

Vol 17, No 3 (2025)
Table of Contents
Review Article
Lifestyle Modifications and Nutraceutical Interventions in the Prevention and Management of Metabolic Syndrome
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya

Research Article
1. APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population
Monica Dwi Hartanti, Ilham Hizbulloh, Janice Puteri Satibi, Ricardo Lie Virgo, Karina Shasri Anastasya, Mizanul Adli, Gerie Amarendra, Agung Junnata

2. Pentagamavunon-1 Enhances the Anticancer Effects of Doxorubicin on Triple-Negative Breast Cancer Cells in Monolayers and 3D Cancer Spheroid Models
Desty Restia Rahmawati, Retno Murwanti, Riris Istighfari Jenie, Arief Nurrochmad

3. MLC 901 Decreases HSP-70, MMP-9, Cerebral Infarction Volume and Functional Outcome in Acute Ischemic Stroke Rat Model
Ilsa Hunaifi, Andi Kurnia Bintang, Jumraini Tammasse, Isra' Wahid, Mohammad Hatta, Andi Asadul Islam, Andi Alfian Zainuddin, Paulus Sugianto

4. Serum CD44 Variant 6 to CD44 Ratio and Vascular Endothelial Growth Factor Levels as Predictors of Metastasis in Luminal Subtype Breast Cancer
Ni Putu Yenny Kendarini, Ida Bagus Tjakra Wibawa Manuaba, I Wayan Sudarsa, Tjokorda Gde Bagus Mahadewa, Ni Nyoman Ayu Dewi, Prayuda Prayuda, Putu Febry Krisna Pertiwi

5. miR-200a as Potential Early-onset Biomarker, while High Nitric Oxide as Potential Late-onset Biomarker in Preeclampsia
Hudila Rifa Karmia, Yusrawati Yusrawati, Jamsari Jamsari, Hardisman Hardisman

6. Anti-thrombocytopenic Activities of 15 Selected Indonesian Medicinal Plants: Psidium guajava Leaves, Phyllanthus niruri Aerial Parts, and Andrographis paniculata Leaves as Potential Sources in Enhancing Platelet Levels in Rats
Yasmiwar Susilawati, Ami Tjitraresmi, Ferry Ferdiansyah Sofian, Eli Halimah, Humaira Praswatika Dewi, Aria Aristokrat

7. Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer
I Nyoman Wawan Tirtha Yasa, I Wayan Sudarsa, I Wayan Niryana, Ni Putu Sriwidyani, I Made Jawi, I Wayan Putu Sutirta Yasa, Ida Bagus Tjakra Wibawa Manuaba, Ida Bagus Made Suryawisesa

8. Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition
Muhammad Ryan Radix Rahardhian, Fahriza Ardiansyah, Yasmiwar Susilawati, Gofarana Wilar, Sri Adi Sumiwi, Jutti Levita, Muchtaridi Muchtaridi

9. Immunomodulatory Effect of Dioscorea esculenta L. on NF-κB, TLR-4, TNF-α, and IL-10 Expressions in LPS-stimulated RAW 264.7 Mouse Macrophages
Ika Puspitaningrum, Muthi Ikawati, Nanang Fakhrudin, Arief Nurrochmad